Resident Population in Mesa County, CO was 159.68100 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Mesa County, CO reached a record high of 159.68100 in January of 2023 and a record low of 54.37400 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Mesa County, CO - last updated from the United States Federal Reserve on May of 2024.